When I was younger, I was determined that I was willing to die on just about EVERY hill. You know what I mean. Everything was vitally important. And I wanted to be “right” about everything that I would be like a bulldog about…everything. As I’ve gotten older, I’ve come to realize that you just don’t need to sweat the small stuff- and an AWFUL lot is “the small stuff”.
Here’s just one small example of what I mean. Back in the day, when I first started proofing church newsletters, I was highly critical of some of the things others wrote. I would read them and think, “I could write this article so much better than that they did!” And then I would start basically rewriting the article.
But over the years, I figured out that my job at that moment was NOT to rewrite someone…
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Last week the Food and Drug Administration (FDA) approved lofexidine for the treatment of opioid withdrawal symptoms, under the brand name Lucemyra.
This medication is an alpha 2a adrenergic receptor agonist, which means it acts on the same receptors as epinephrine and norepinephrine. However, when the specific alpha 2a receptors are activated, less norepinephrine is released, and so the actions of epinephrine and norepinephrine are reduced.
Lofexidine is not an opioid, and has no effect on the opioid receptors. It doesn’t cause euphoria or intoxication and thus is not a controlled substance.
So, you may be wondering, how does this medication help with opioid withdrawal?
Among many other places in the central nervous system, opioids act on a part of the brain called the locus ceruleus. The locus ceruleus, which in Latin means the “blue place,” is part of the system that controls the autonomic nervous system. When locus ceruleus…
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I have been told that I have some of the STRANGEST stories around…well…here you go! When my oldest son was about 8 years old, I had the pleasure (?) of serving as the “warm up act” for the Miss Illinois Pageant. (Don’t ask…it’s a LONG and rather dull story!) As I have mentioned before, I am a magician/juggler, and they needed someone to come and simply warm up the crowd. I was NOT televised or featured- instead, I was the sacrificial lamb who was led out to get the crowd “off their hands” as they say and get them ready to make some noise. SO…I packed up my cases AND my son, who wanted to serve as my “assistant”, and headed out. What I found was rather interesting! There were people there who were glad to see me, seemed to thoroughly enjoy the show, and responded accordingly. And then I…
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Long-time readers of my blog will recall that I broke my leg – tibia and fibula – around six years ago. The point of the post was mainly to get to talk about my medical ailments, which I love, and that opioids, when used correctly, can be a huge blessing. I described how EMS personnel, on the way to the hospital, gave me a dose of fentanyl. The relief of intense pain was so miraculous.
Well, now I get to talk about my latest medical adventure.
I had a tibial intramedullary rod placed when I broke my leg. It worked beautifully and allowed my broken leg to heal much more quickly. I was ultimately able to get back to my usual activities after what could have been a devastating accident, had good medical treatment not been available.
But starting a few years ago, I had some swelling right at the…
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